Product Name: Proparacaine hydrochloride
Synonyms: 2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate
chloride;Proparacaine hydrochloride, >=99%;PROPARACAINE
Melting point 182.0-183.3℃
Usage: Anesthetic;Neuronal conductance inhibitor
Proparacaine Hydrochloride Ophthalmic Solution USP, 0.5% is a local
anesthetic for ophthalmic instillation. Each mL of sterile, aqueous
solution contains: Active: Proparacaine Hydrochloride 5 mg (0.5%).
Inactives: Glycerin as a stabilizer, Hydrochloric Acid and/or
Sodium Hydroxide may be added to adjust pH (3.5 to 6.0), and Water
for Injection. Preservative: Benzalkonium Chloride 0.1 mg (0.01%).
Proparacaine hydrochloride is designed chemically as
2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate monohydrochloride.
The active ingredient is represented by the structural formula:
Proparacaine Hydrochloride Ophthalmic Solution is a rapid acting
local anesthetic suitable for ophthalmic use. With a single drop,
the onset of anesthesia begins within 30 seconds and persists for
15 minutes or longer.
The main site of anesthetic action is the nerve cell membrane where
Proparacaine interferes with the large transient increase in the
membrane permeability to sodium ions that is normally produced by a
slight depolarization of the membrane. As the anesthetic action
progressively develops in a nerve, the threshold for electrical
stimulation gradually increases and the safety factor for
conduction decreases; when this action is sufficiently well
developed, block of conduction is produced.
The exact mechanism whereby Proparacaine and other local
anesthetics influence the permeability of the cell membrane is
unknown; however, several studies indicate that local anesthetics
may limit sodium ion permeability by closing the pores through
which the ions migrate in the lipid layer of the nerve cell
membrane. This limitation prevents the fundamental change necessary
for the generation of the action potential.
INDICATIONS AND USAGE:
Proparacaine Hydrochloride Ophthalmic Solution is indicated for
topical anesthesia in ophthalmic practice. Representative
ophthalmic procedures in which the preparation provides good local
anesthesia include measurement of intraocular pressure (tonometry),
removal of foreign bodies and sutures from the cornea, conjunctival
scraping in diagnosis and gonioscopic examination; it is also
indicated for use as a topical anesthetic prior to surgical
operations such as cataract extraction.
Local Anesthetic Powder
|Benzocaine HCL||Procaine HCL||Lidocaine HCL||Tetracaine HCL|
|Dimethocaine||Prilocaine||Articaine HCL||Pramoxine HCL|
|Dimethocaine HCL||Prilocaine HCL||Bupivacaine HCL||Proparacaine HCL|